Snake bites in pediatric hand and their local complications.

Authors

  • Lucía d' Oliveira Doctor in medicine. Specialist in Plastic Surgery. Centro Hospitalario Pereira Rossell, Montevideo, Uruguay. https://orcid.org/0000-0001-8567-0000
  • Eliana Camacho Doctor of Medicine. Facultad de Medicina, Universidad de la República. Residente de Cirugía Plástica, Reconstructiva y Estética, Hospital de Clínicas Dr. Manuel Quintela, Departamento de Cirugía Plástica, Montevideo, Uruguay. https://orcid.org/0000-0001-5567-6858
  • Ivana Armand Hugon Doctor of Medicine. Facultad de Medicina, Universidad de la República. Residente de Cirugía Plástica, Reconstructiva y Estética, Hospital de Clínicas Dr. Manuel Quintela, Departamento de Cirugía Plástica, Montevideo, Uruguay. https://orcid.org/0000-0002-1799-9848
  • Matías Craviotto Doctor of Medicine. Plastic Surgeon. Clínica de Rehabilitación de la Mano, Montevideo, Uruguay. https://orcid.org/0000-0002-0529-2351

DOI:

https://doi.org/10.35954/SM2022.41.2.4.e402

Keywords:

Snake Bite Poisoning; Fasciotomy; Snake Bites; Snake Bites /Pediatric; Child; Pediatric; Compartment Syndrome; Snake Venoms.

Abstract

Introduction: Ophidian bite poisoning is recognized as a public health problem by the World Health Organization. The low incidence added to the diversity of clinical presentations, ages, affected topographies, as well as the different protocols in the existing literature on some aspects of treatment, make the systematized management of these patients difficult. The aim of this work is to carry out a systematic review of the literature on snakebite in pediatric patients with hand and upper limb involvement, with emphasis on the management of loco-regional complications. In terms of importance and frequency, we highlight compartment syndrome, phlyctenas and infections. 

Methodology: a literature search was carried out in MedLine/PubMed with the keywords: "Snake Bite hand Children" and "Snake Bite compartment syndrome". Articles published in the last 10 years (2012 to 2022) were included.

Results: the search for articles with the words "Snake Bite hand Children" resulted in 20 articles and the search for the words "Snake Bite compartment syndrome" resulted in 34 articles. After applying the inclusion and exclusion criteria, 30 articles were obtained for the analysis.

Conclusions: the pediatric population is more exposed to snake bites and in turn to present more severe lesions. The treatment of compartment syndrome continues to be a subject of debate. Inoculated venom can simulate a compartment syndrome that can be reversed without fasciotomies with proper treatment. Likewise, in the presence of clear symptoms and signs of compartment syndrome, fasciotomies are suggested because of the serious sequelae generated. In the event of the appearance of phlyctenas, careful unroofing of the phlyctenas would be an appropriate treatment. Most authors agree with prophylactic treatment with antibiotic therapy.

Received for review: February 2022.
Accepted for publication: May 2022.
Correspondence: Av. Italia S/N. C.P. 11600. Montevideo, Uruguay. Tel: (+598) 99121777.

Contact e-mail: lucia@cirugiaplasticapediatrica.com.uy

Contact e-mail: lucia@cirugiaplasticapediatrica.com.uyContact e-mail: lucia@cirugiaplasticapediatrica.com.uyphylactic treatment with antibiotic therapy.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Author Biographies

Lucía d' Oliveira, Doctor in medicine. Specialist in Plastic Surgery. Centro Hospitalario Pereira Rossell, Montevideo, Uruguay.

CONTRIBUTED TO THE MANUSCITE IN: Conception, design, data acquisition, data analysis, interpretation and discussion of results, drafting and critical revision, and approval of the final version.

Eliana Camacho , Doctor of Medicine. Facultad de Medicina, Universidad de la República. Residente de Cirugía Plástica, Reconstructiva y Estética, Hospital de Clínicas Dr. Manuel Quintela, Departamento de Cirugía Plástica, Montevideo, Uruguay.

CONTRIBUTED TO THE MANUSCITIOUS IN: data acquisition and data analysis.

Ivana Armand Hugon, Doctor of Medicine. Facultad de Medicina, Universidad de la República. Residente de Cirugía Plástica, Reconstructiva y Estética, Hospital de Clínicas Dr. Manuel Quintela, Departamento de Cirugía Plástica, Montevideo, Uruguay.

CONTRIBUTED TO THE MANUSCITIOUS IN: acquisition of data and interpretation and discussion of results.

Matías Craviotto, Doctor of Medicine. Plastic Surgeon. Clínica de Rehabilitación de la Mano, Montevideo, Uruguay.

CONTRIBUTED TO THE MANUSCITE IN: data analysis, writing and critical review.

References

(1) Gutierrez J, Calvete J, Habib A, Harrison R, Williams D, Warrel D. Snakebite envenoming. Nature Reviews Disease Primers 2017; 3:1-21. https://doi.org/10.1038/nrdp.2017.63

(2) Universidad de la República. Hospital de Clínicas. Cátedra de toxicología, 2022.

(3) Mao YC, Liu PY, Chiang LC, Lee CH, Lai CS, Lai KL, et al. Clinical manifestations and treatments of Protobothrops mucrosquamatus bite and associated factors for wound necrosis and subsequent debridement and finger or toe amputation surgery. Clin Toxicol (Phila) 2021; 59(1):28-37. doi: 10.1080/15563650.2020.1762892.

(4) Variawa S, Buitendag J, Marais R, Wood D, Oosthuizen G. Prospective review of cytotoxic snakebite envenomation in a paediatric population. Toxicon 2021; 190:73-78. doi: 10.1016/j.toxicon.2020.12.009.

(5) Tekin R, Sula B, Cakırca G, Aktar F, Deveci Ö, Yolbas I, et al. Comparison of snakebite cases in children and adults. Eur Rev Med Pharmacol Sci 2015; 19(14):2711-6. PMID: 26221904.

(6) Brenes-Chacón H, Gutiérrez JM, Camacho-Badilla K, Soriano-Fallas A, Ulloa-Gutierrez R, Valverde-Muñoz K, Ávila-Agüero ML. Snakebite envenoming in children: A neglected tropical disease in a Costa Rican pediatric tertiary care center. Acta Trop 2019; 200:105176. doi: 10.1016/j.actatropica.2019.105176.

(7) Barani C, Mortamet G, Forli A. Upper limb compartment syndrome after a viper bite in a child: A case report. Hand Surg Rehabil 2021; 40(1):97-100. doi: 10.1016/j.hansur.2020.07.003.

(8) Geron M, Kumar R, Matzner H, Lahiani A, Gincberg G, Cohen G, et al. Protein toxins of the Echis coloratus viper venom directly activate TRPV1. Biochim Biophys Acta 2017; 1861(3):615–623.

(9) Glatstein M, Lerman L, Friedman S, Carbell G, Munchak I, Valla U, et al. Severe disseminated intravascular coagulation in a child envenomated by Echis coloratus and successful treatment with monovalent equine immunoglobulin G antivenom. Toxicon 2019; 167:82-86. doi: 10.1016/j.toxicon.2019.05.012.

(10) Tortorela MN, Negrin A, Pacareu V. Actualización de tratamiento en mordedura de ofidios y arácnidos. [Internet]. Disertación webinar. Mayo 2022.

(11) da Silva AM, Colombini M, Moura-da-Silva AM, de Souza RM, Monteiro WM, Bernarde PS. Ethno-knowledge and attitudes regarding snakebites in the Alto Juruá region, Western Brazilian Amazonia. Toxicon 2019; 171:66-77. doi: 10.1016/j.toxicon.2019.10.238.

(12) Regional Office for South-East Asia. World Health Organization. Guidelines for the management of snakebites, 2nd ed. WHO Regional Office for South-East Asia, 2016. Available from: https://apps.who.int/iris/handle/10665/249547 [Consulted 04/02/2022].

(13) Edgerton MT, Koepplinger ME. Management of Snakebites in the Upper Extremity. J Hand Surg Am 2019; 44(2):137-142. doi: 10.1016/j.jhsa.2018.06.016.

(14) Carvalho J, Moinho R, Macao P, Oliveira G. When snakebites complicate: a paediatric case with shock and compartment syndrome. BMJ Case Rep 2021; 14(2):e240206. doi: 10.1136/bcr-2020-240206.

(15) Glatstein M, Lerman L, Friedman S, Carbell G, Munchak I, Valla U, et al. Severe disseminated intravascular coagulation in a child envenomated by Echis coloratus and successful treatment with monovalent equine immunoglobulin G antivenom. Toxicon 2019; 167:82-86. doi: 10.1016/j.toxicon.2019.05.012.

(16) Gold BS, Barish RA, Dart RC, Silverman RP, Bochicchio GV. Resolution of compartment syndrome after rattlesnake envenomation utilizing non-inva- sive measures. J Emerg Med 2003; 24:285-8.

(17) Garfin SR, Castilonia RR, Mubarak SJ, Hargens AR, Akeson WH, Russell FE. The effect of antivenin on intramuscular pressure elevations induced by rattle- snake venom. Toxicon 1985; 23:677-80.

(18) Darracq MA, Cantrell FL, Klauk B, Thornton SL. A chance to cut is not always a chance to cure- fasciotomy in the treatment of rattlesnake envenomation: A retrospective poison center study. Toxicon 2015; 101:23-6. doi: 10.1016/j.toxicon.2015.04.014.

(19) Hsu CP, Chuang JF, Hsu YP, Wang SY, Fu CY, Yuan KC, et al. Predictors of the development of post-snakebite compartment syndrome. Scand J Trauma Resusc Emerg Med 2015; 23:97. doi: 10.1186/s13049-015-0179-y.

(20) Livingston KS, Glotzbecker MP, Shore BJ. Pediatric Acute Compartment Syndrome. J Am Acad Orthop Surg 2017; 25(5):358-364. doi: 10.5435/JAAOS-D-15-00655.

(21) Ince B, Gundeslioglu AO. The management of viper bites on the hand. J Hand Surg Eur 2014; 39(6):642-6. doi: 10.1177/1753193413496943.

(22) Russell FE, Carlson RW, Wainschel J, Osborne AH. Snake Venom Poisoning in the United States: Experiences With 550 Cases. JAMA 1975; 233(4):341–344. doi:10.1001/jama.1975.03260040035020.

(23) Pietrangiolillo Z, Frassoldati R, Leonelli V, Freschi R, Russomando A, Lucaccioni L, et al. Compartment syndrome after viper-bite in toddler: case report and review of literature. Acta Biomed 2012; 83(1):44-50.

(24) Dhar D. Compartment Syndrome Following Snake Bite. Oman Med J 2015; 30(2):e082. doi: 10.5001/omj.2015.32.

(25) Türkmen A, Temel M. Algorithmic approach to the prevention of unnecessary fasciotomy in extremity snake bite. Injury 2016; 47(12):2822-2827. doi: 10.1016/j.injury.2016.10.023.

(26) Kim YH, Choi JH, Kim J, Chung YK. Fasciotomy in compartment syndrome from snakebite. Arch Plast Surg 2019; 46(1):69-74. doi: 10.5999/aps.2018.00577.

(27) Ramirez RN, Umberhandt R, Oishi SN, Ezaki M. Digital Chondrolysis and Epiphysiolysis Associated With Snakebite: A Report of 2 Cases. J Pediatr Orthop 2015; 35(6):e60-4. doi: 10.1097/BPO.0000000000000499.

(28) Karabuva S, Vrkić I, Brizić I, Ivić I, Lukšić B. Venomous snakebites in children in southern Croatia. Toxicon [Internet] 2016; 112:8–15. Available from: http://dx.doi.org/10.1016/j.toxicon.2016.01.057

(29) Faiz MA, Ahsan MF, Ghose A, Rahman MR, Amin R, Hossain M, et al. Bites by the Monocled Cobra, Naja kaouthia, in Chittagong Division, Bangladesh: Epidemiology, clinical features of envenoming and management of 70 identified cases. Am J Trop Med Hyg 2017; 96(4):876–84.

(30) Sadeghi M, Barazandeh M, Zakariaei Z, Davoodi L, Tabaripour R, Fakhar M, et al. Massive cutaneous complications due to snakebite: A case report and literature review. Clin Case Reports 2021; 9(5):1-5.

(31) Lin CC, Wang PJ, Liu CC. Venom concentrations in blisters and hemorrhagic bullae in a patient bitten by a Taiwan habu (Protobothrops mucrosquamatus). Rev Soc Bras Med Trop 2019; 52:e20180160.

(32) Gnaneswaran N, Perera E, Perera M, Sawhney R. Cutaneous chemical burns: assessment and early management. Aust Fam Physician 2015; 44(3):135-9.

(33) Macêdo JKA, Joseph JK, Menon J, Escalante T, Rucavado A, Gutiérrez JM, et al. Proteomic analysis of human blister fluids following envenomation by three snake species in India: Differential markers for venom mechanisms of action. Toxins (Basel) 2019; 11(5):246. doi: 10.3390/toxins11050246.

(34) Vohra R, Rangan C, Bengiamin R. Sonographic signs of snakebite. Clin Toxicol (Phila) 2014; 52(9):948-51. doi: 10.3109/15563650.2014.958613.

Published

2022-07-04

How to Cite

1.
d’ Oliveira L, Camacho E, Armand Hugon I, Craviotto M. Snake bites in pediatric hand and their local complications. Salud Mil [Internet]. 2022 Jul. 4 [cited 2026 Apr. 18];41(2):e402. Available from: https://revistasaludmilitar.uy/ojs/index.php/Rsm/article/view/322

Issue

Section

Reviews

        PlumX Metrics