Non-Hodgkin's lymphoma: use of gamma emitters for diagnosis.
DOI:
https://doi.org/10.35954/SM2015.34.1.7Keywords:
Cancer; Gamma emitters; Non-Hodgkin's lymphoma; Positron emission; PositronsAbstract
24.8% of deaths in Uruguay are due to cancer. Non-Hodgkin's lymphoma (NHL) is the most frequent hematological neoplasm and the fifth cause of cancer death in the world; more than 90% of the cases are caused by B lymphocytes and express the CD20 antigen. The monoclonal antibody Rituximab® recognizes this surface antigen with high affinity and is used in the treatment of CD20-positive NHL. Currently, in addition to Rituximab®, the FDA has approved the use of the anti-CD20 antibody associated with beta emitters (1311, 90Y), which enhance its effect and increase its therapeutic effectiveness.
The present work aims to demonstrate that the development of new imaging agents using monoclonal antibodies directed against specific cell surface targets and coupled to conventional gamma emitters or positron emitters would improve the sensitivity and specificity of imaging for the statification of this pathology.
Received for review: March 2015
Accepted for publication: June 2015
Correspondence: Radiopharmacy Laboratory, Nuclear Research Center, Faculty of Sciences, Universidad de la Republica. Mataojo 2055, C.P. 11400, Montevideo, Uruguay. Tel: (+598)25250901/108; fax: (+598)25250895.
Contact e-mail: pcabral@cin.edu.uy
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