Utilización de Modelos animales en investigación del cáncer
DOI:
https://doi.org/10.35954/SM2012.31.1.7Keywords:
Cancer; Experimentation; Animal models.Abstract
In parallel with the development of knowledge of the different physiologies and pathologies in the human and animal area, animal models were discovered and/or created, which turned out to be a fundamental tool for the knowledge and understanding of the physiology and pathogenesis of different diseases and possible therapies. The following work has the purpose of making a brief review about animal models in experimentation and cancer research, their definition, classification, the pros and cons about their use, animal handling as well as their monitoring, ethical aspects and endpoint criteria.
Received for review: June 2012.
Accepted for publication: August 2012.
Downloads
References
(1) Benavidez F, Genet JL. Modelos murinos de enfermedades humanas. Medicina 2001; 61(2):215- 231.
(2) Euhus, et al. Tumor Measurement in the Nude Mouse. Journal of Surgical Oncology 1986; 31:229-234.
(3) Attia M, Weiss DW. Immunology of Spontaneous Mammary Carcinomas in Mice V. Acquired Tumor Resistance and Enhancement in Strain A Mice Infected with Mammary Tumor Virus. Cancer Research 1966; 26(8 part 1):1787-1800.
(4) Foltz Charmine J, et al. Guidelines for assessing the health condition of mice. Lab Animal 1999; 28(4):28-32.
(5) Irwin S. Comprehensive observational assessment: In: A systematic, quantitative procedure for assessing the behavioral and physiologic state of the mouse. Psychopharmacology 1968; 13:222-257.
(6) Morton, DB. A Systemic Approach for Establishing Humane Endpoints. ILAR J 2000; 41(2):80-86.
(7) Public Health Service. Policy on humane care and use of laboratory animals. Olaw, 2002. Disponible en: http://grantsl.nih.gov/grants/olaw/references/phspol.htm [Consulta: 30/07/2012].
(8) Tomasovic SP, Coghlan LG, Gray KN, et al. IACUC Evaluation of Experiments Requiring Death as an End Point: A Cancer Center’s Recommendations. Lab Animal 1988; 17(1):31-34.
(9) United Kingdom Coordinating Committee on Cancer Research. Guidelines for the Welfare of Animals in Experimental Neoplasia. British Journal of Cancer 1998; 77(1):1-10.
(10) Wallace J. Humane Endpoints in cancer research. ILAR J 2000; 41(2):87-93.
Published
How to Cite
Issue
Section
License
Until 2024 we use the Creative Commons Attribution/NonCommercial Attribution 4.0 International License https://creativecommons.org/licenses/by-nc/4.0/deed.es. Which states that: you are free to share, copy and redistribute the material in any medium or format, as well as to adapt, remix, transform and build upon the material. Under the following terms:
Attribution: you must give proper credit , provide a link to the license, and indicate if changes have been made . You may do so in any reasonable manner, but not in such a way as to suggest that you or your use is endorsed by the licensor.
NonCommercial: you may not use the material for commercial purposes.
As of 2025 authors retain their copyright and assign to the journal the right of first publication of their work, which shall simultaneously be subject to the license https://creativecommons.org/licenses/by-nc-sa/4.0/deed.es that permits sharing, copying and redistribution of the material in any medium or format provided that initial publication in this journal is indicated. Adapt, remix, transform and build upon the material. If you remix, transform, or build from the material, you must distribute your contribution under the same license as the original and may not make use of the material for commercial purposes.
Under the following terms:
1. Attribution: you must give proper credit, provide a link to the license, and indicate whether changes have been made. You may do so in any reasonable manner, but not in such a way as to suggest that you or your use is endorsed by the licensor.
2. NonCommercial: you may not use the material for commercial purposes.
3. ShareAlike: if you remix, transform or build upon the material, you must distribute your contribution under the same license as the original.
PlumX Metrics
/
