Effect of platelet-rich fibrin in the postoperative period of mandibular third molar surgery.
DOI:
https://doi.org/10.35954/SM2020.39.2.3Keywords:
Postoperative Complications; Tooth, Impacted; Tooth Extraction; Platelet-Rich Fibrin; Oral Surgical Procedures; Molar, ThirdAbstract
Objectives: To evaluate platelet-rich fibrin as a healing enhancer and its possible effect on the reduction of morbidities associated with retained and semi-retained mandibular third molar surgery. To report the causal factors of mandibular third molar retention and the possible complications associated with the surgical extraction of the mandibular third molar. Describe the principle and function of platelet concentrates, their clinical applications and mechanisms of action. To provide a comprehensive review of the published oral and maxillofacial literature on platelet-rich fibrin, how it evolved and developed to where it is today; and what are its biological characteristics, composition, performance protocol and how these key elements function within the clinical setting. Methodology: To obtain data for this article we consulted the Medline/Pubmed database and the Timbo Foco portal, without applying time limits, in English, Spanish and Portuguese, as well as texts used in the Doctor of Dentistry program at the Universidad de la Republica. Potentially relevant studies analyzing the effect of platelet-rich fibrin in the healing process after mandibular retained and semi-retained third molar surgery and evaluating its possible beneficial effect on postoperative complications associated with this procedure were reviewed. Conclusions: It is confirmed that platelet-rich fibrin decreases but does not prevent some of the postoperative complications associated with mandibular third molar surgery achieving a significant improvement in pain, edema and decrease in the incidence of alveolitis. Platelet-rich fibrin appears to accelerate healing in mandibular third molar surgery by inducing soft and hard tissue regeneration. The platelet-rich fibrin preparation procedure is simple and cost-effective making its use attractive to many clinicians and can be applied in outpatient clinical settings.
Recibido para evaluación:Febrero 2020 Aceptado para publicación:Agosto 2020
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(1) Canellas JVDS, Ritto FG, Medeiros PJD. Evaluation of postoperative complications after mandibular third molar surgery with the use of platelet-rich fibrin: a systematic review and meta-analysis. Int J Oral Maxillofac Surg. 2017; 46(9):1138‐1146. doi:10.1016/j.ijom.2017.04.006
(2) Xiang X, Shi P, Zhang P, Shen J, Kang J. Impact of platelet-rich fibrin on mandibular third molar surgery recovery: a systematic review and meta-analysis. BMC Oral Health [Internet]. 2019 Jul 1 [cited 2020 Jun 13]; 19(1):1-10. Available from: http://search.ebscohost.com.proxy.timbo.org.uy:2048/login.aspx?direct=true&db=edsdoj&AN=edsdoj.8be1baaa9d94982bedda8f25b85f752&lang=es&site=eds-live
(3) Surekha K, Gudipalli S, Peramulla P, Prathima T, Kumar Y, Budumuru A. Efficacy of autologous platelet-rich fibrin in osseous regeneration after mandibular third molar surgery: A comparative study. Journal of Dr NTR University of Health Sciences [Internet]. 2019 Jan 1 [cited 2020 Aug 14]; 8(1):37-41. Available from: http://search.ebscohost.com.proxy.timbo.org.uy:2048/login.aspx?direct=true&db=edsdoj&AN=edsdoj.313e118da4e45b850d8f938787759&lang=es&site=eds-live
(4) Bachmann H, Cáceres R, Muñoz C, Uribe S. Complicaciones en Cirugía de Terceros Molares entre los Años 2007-2010, en un Hospital Urbano, Chile. International journal of odontostomatology [Internet]. 2014 Apr 1 [cited 2020 Jul 4]; 8(1):107-12. Disponible en: http://search.ebscohost.com.proxy.timbo.org.uy:2048/login.aspx?direct=true&db=edssci&AN=edssci.S0718.381X2014000100014&lang=es&site=eds-live
(5) Kumar Pillai A, Thomas S, Paul G, Singh SK, Moghe S. Incidence of impacted third molars: A radiographic study in People’s Hospital, Bhopal, India. J Oral Biol Craniofac Res 2014; 4(2):76‐81. doi:10.1016/j.jobcr.2014.04.001
(6) Sánchez-Gutiérrez C, Cepeda-Bravo JA, Fierro-Serna VM, García-García Carlos E, Martínez-Rider R, Noyola-Frías MA. Eficacia del uso de Plasma rica en factores de crecimiento en defectos periodontales distales ensegundos molares inferiores, posterior a la extracción de un tercer molar mandibilar. Rev Esp Cirug Oral y Maxilofac [Internet]. 2017 Sep [cited 2020 June 12]; 39(3): 164-170. Disponible en: http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-05582017000300164&lng=en. http://dx.doi.org/10.1016/j.maxilo.2016.04.001.
(7) Crestanello Nese J. Aspectos controversiales en relación al manejo de los terceros molares asintomáticos. Actas Odontológicas 2010; 7 (2): 63-76.
(8) Cho H, Lynham AJ, Hsu E. Postoperative interventions to reduce inflammatory complications after third molar surgery: review of the current evidence. Australian dental journal [Internet]. 2017 Dec [cited 2020 Jul 4]; 62(4):412-9. Available from: http://search.ebscohost.com.proxy.timbo.org.uy:2048/login.aspx?direct=true&db=cmedm&AN=28498604&lang=es&site=eds-live
(9) Rodríguez Aguirre GC, Martínez Herrera E, Duque Serna FL, Londoño Puerta LM. Caracterización de terceros molares sometidos a exodoncia quirúrgica en la Facultad de Odontología de la Universidad de Antioquia entre 1991 y 2001. Rev Fac Odontol Univ Antioq [Internet]. 2009Nov.6 [cited 2020Jun.12]; 18(2). Disponible en: https://revistas.udea.edu.co/index.php/odont/article/view/2763
(10) Ghanaati S, Herrera-Vizcaino C, Al-Maawi S, Lorenz J, Miron RJ, Nelson K, et al. Fifteen Years of Platelet Rich Fibrin in Dentistry and Oromaxillofacial Surgery: How High is the Level of Scientific Evidence? The Journal of oral implantology [Internet]. 2018 Dec [cited 2020 Jun 13]; 44(6):471-92. Available from: http://search.ebscohost.com.proxy.timbo.org.uy:2048/login.aspx?direct=true&db=cmedm&AN=29870308&lang=es&site=eds-live
(11) Raman S, Bhoj M, Madhulaxmi M, Jeevanandam G. Application of platelet-rich fibrin in oral and maxillofacial surgery - A short review. Drug Invention Today [Internet]. 2019 Mar 15 [cited 2020 Jun 12]; 12(3):456–62. Available from: http://search.ebscohost.com.proxy.timbo.org.uy:2048/login.aspx?direct=true&db=asn&AN=135900214&lang=es&site=eds-live
(12) Saluja H, Dehane V, Mahindra U. Platelet-Rich fibrin: A second generation platelet concentrate and a new friend of oral and maxillofacial surgeons. Annals of Maxillofacial Surgery [Internet]. 2011 Mar [cited 2020 Jun 15]; 1(1):53. Available from: http://search.ebscohost.com.proxy.timbo.org.uy:2048/login.aspx?direct=true&db=edb&AN=64753592&lang=es&site=eds-live
(13) Mihaylova Z, Mitev V, Stanimirov P, Isaeva A, Gateva N, Ishkitiev N. Use of platelet concentrates in oral and maxillofacial surgery: an overview. Acta odontologica Scandinavica [Internet]. 2017 Jan [cited 2020 Jun 13]; 75(1):1-11. Available from: http://search.ebscohost.com.proxy.timbo.org.uy:2048/login.aspx?direct=true&db=cmedm&AN=27669885&lang=es&site=eds-live doi:10.1080/00016357.2016.1236985
(14) Marenzi G, Di Lauro A, Sammartino G, Riccitiello F, Tia M. Influence of leukocyte- and platelet-rich fibrin (L-PRF) in the healing of simple postextraction sockets: A split-mouth study. BioMed Research International [Internet]. [Cited 2020 Jun 13]; 2015. Available from: http://search.ebscohost.com.proxy.timbo.org.uy:2048/login.aspx?direct=true&db=edselc&AN=edselc.2-52.0-84939208854&lang=es&site=eds-live do 10.1155/2015/369273 i:
(15) Del Fabbro M, Bortolin M, Taschieri S. Is autologous platelet concentrate beneficial for post-extraction socket healing? A systematic review. Int J Oral Maxillofacial Surg 2011; 40(9):891-900. doi:10.1016/j.ijom.2011.04.009
(16) Correa AJ, Alister JP, Olate S, Manterola C. L-PRF y Ciclo Celular Revisión narrativa. Int J Odontostomat 2019; 13(4):497-503.
(17) Feigin K, Shope B. Use of Platelet-Rich Plasma and Platelet-Rich Fibrin in Dentistry and Oral Surgery: Introduction and Review of the Literature. Journal of Veterinary Dentistry [Internet]. 2019 Jun [cited 2020 Jun 13]; 36(2):109. Available from: http://search.ebscohost.com.proxy.timbo.org.uy:2048/login.aspx?direct=true&db=edo&AN=139414095&lang=es&site=eds-live
(18) Plachokova AS, Nikolidakis D, Jansen JA, Mulder J, Creugers NHJ. Effect of platelet-rich plasma on bone regeneration in dentistry: A systematic review. Clin Oral Impl Res 2008; 19(6):539-45. doi:10.1111/j.1600-0501.2008.01525.x
(19) Hartshorne J, Gluckman H. A comprehensive clinical review of Platelet Rich Fibrin PRF) and its role in promoting tissue healing and regeneration in dentistry. Part 1: Definition, development, biological characteristics and function. International Dentistry South Africa [Internet]. 2016 Oct [cited 2020 Jun 16]; 6(5):14. Available from: http://search.ebscohost.com.proxy.timbo.org.uy:2048/login.aspx?direct=true&db=edb&AN=126887540&lang=es&site=eds-live
(20) Canellas JV d. S, Medeiros PJD, Figueredo CM d. S, Fischer RG, Ritto FG. Platelet-rich fibrin in oral surgical procedures: a systematic review and meta-analysis. Int J Oral Maxillofacial Surg 2019; 48(3):395-414. doi: 10.1016/j.ijom.2018.07.007
(21) Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJJ, Mouhyi J, et al. Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part I: Technological concepts and evolution. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology [Internet]. 2006 Jan 1 [cited 2020 Jun 15]; 101(3):e37-44. doi: 10.1016/j.tripleo.2005.07.008
(22) Assad M, Bitar W, Alhajj MN. Closure of Oroantral Communication Using Platelet-rich Fibrin: A Report of Two Cases. Annals of maxillofacial surgery [Internet]. 2017 Jan [cited 2020 Jun 13]; 7(1):117-9. Available from: http://search.ebscohost.com.proxy.timbo.org.uy:2048/login.aspx?direct=true&db=cmedm&AN=28713748&lang=es&site=eds-live
(23) Gutiérrez Ramirez DA, Hinojosa Sarria JP, Restrepo Dorado AI, Muñoz Ramírez AL, Velarde trochez NF, Bastidas Daza FE. Análisis estructural de la fibrina rica en plaquetas y sus aplicaciones en odontología regenerativa. Univ Odontol.2018; 37(79). https://doi.org/10.11144/Javeriana.uo37-79.aefr
(24) Simon BI, Gupta P, Tajbakhsh S. Quantitative evaluation of extraction socket healing following the use of autologous platelet-rich fibrin matrix in humans. International Journal of Periodontics and Restorative Dentistry [Internet]. [Cited 2020 Jun 14]; 31(3):285-95. Available from: http://search.ebscohost.com.proxy.timbo.org.uy:2048/login.aspx?direct=true&db=edselc&AN=edselc.2-52.0-79960933109&lang=es&site=eds-live
(25) Miyamoto H, Nakamura T, Takashima H, Mizutani T, Morita M, Hirose M, et al. Investigation of the analgesic effect of platelet-rich fibrin on postoperative pain after mandibular impacted wisdom tooth extraction. Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology [Internet]. 2020 Jan 1 [cited 2020 Jul 3]; Available from: http://search.ebscohost.com.proxy.timbo.org.uy:2048/login.aspx?direct=true&db=edselp&AN=S2212555820300235&lang=es&site=eds-live doi: 10.1016/j.ajoms.2020.03.001
(26) Guzmán Castillo GF, Paltas Miranda ME, Benenaula Bojorque JA, Núñez Barragán Katerine I, Simbaña García DV. Cicatrización de tejido óseo y gingival en cirugías de terceros molares inferiores. Estudio comparativo entre el uso de fibrina rica en plaquetas versus cicatrización fisiológica. Rev. Odont. Mex [revista en la Internet]. 2017 Jun [citado 2020 Jun 23]; 21(2): 114-120. Disponible en: http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S1870-199X2017000200114&lng=es. http://dx.doi.org/10.1016/j.rodmex.2017.05.07
(27) Gay Escoda C, Piñera Penalva M, Valmaseda Castellón E. Cordales incluidos. Exodoncia quirúrgica.Complicaciones. En: Cosme Gay Escoda, Leonardo Berini Aytes. Tratado de Cirugia Bucal. Tomo 1. pp. 436, 437, 456, 454, 455, 441, 442.
(28) Asutay F, Yolcu Ü, Geçör O, Acar AH, Öztürk SA, Malkoç S. An evaluation of effects of platelet-rich-fibrin on postoperative morbidities after lower third molar surgery. Niger J Clin Pract 2017; 20(12):1531‐1536. doi: 10.4103/1119-3077.181400
(29) Daly B, Sharif MO, Newton T, Jones K, Worthington HV. Local interventions for the management of alveolar osteitis (dry socket) (Intervenciones locales para el tratamiento de la osteítis alveolar (alveolo seco) Cochrane Database of Systematic Reviews 2012, Issue 12. Art. No.: CD006968. doi: 10.1002/14651858.CD006968.pub2
(30) de Almeida Barros Mourão CF, Alves GG, de Mello Machado RC, Calasans-Maia MD, Miron RJ, Ghanaati S. Usefulness of platelet-rich fibrin as a hemostatic agent after dental extractions in patients receiving anticoagulant therapy with factor Xa inhibitors: a case series. Oral and Maxillofacial Surgery 2019 [Internet]. [Cited 2020 Jun 23]; 23(3):381-6. Available from: http://proxy.timbo.org.uy/login?url=http://search.ebscohost.com/login.aspx?direct=true&db=edselc&AN=edselc.2-52.0-85066025289&lang=es&site=eds-live
(31) Blakey G. Extracciones de los terceros molars. En: Mehra P, D‘Innocenzo R. Manual de Cirigia Oral Menor para el Odontologo General. 2a ed. Amolca, 2019. p. 80.
(32) Khojasteh A, Hosseinpour S, Nazeman P, Dehghan MM. The effect of a platelet-rich fibrin conduit on neurosensory recovery following inferior alveolar nerve lateralization: a preliminary clinical study. International Journal of Oral & Maxillofacial Surgery [Internet]. 2016 Oct 1 [cited 2020 Jun 14]; 45(10):13038. doi:10.1016/j.ijom.2016.06.003. Available from:http://search.ebscohost.com.proxy.timbo.org.uy:2048/login.aspx?direct=true&db=edselp&AN=S0901502716301011&lang=es&site=eds-live
(33) Huang M-L, Zhai Z, Chen Z-X, Yang X-N, Qi Z-L. Platelet-rich fibrin membrane nerve guidance conduit: a potentially promising method for peripheral nerve injuries. Chinese medical journal [Internet]. [Cited 2020 Jul 3]; 133(8):999-1001. Available from: http://search.ebscohost.com.proxy.timbo.org.uy:2048/login.aspx?direct=true&db=edselc&AN=edselc.2-52.0-85083913781&lang=es&site=eds-live
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