Ergotism and antiretroviral protease inhibitors

Authors

  • Rosa Almeida
  • Leonardo Tolosa

DOI:

https://doi.org/10.35954/SM2018.37.2.7

Keywords:

Anti-Retroviral Agents, Ergotism, Lower Extremity, Ischemia; Coronary Vasospasm

Abstract

Ergotism is an entity characterized by vasospasms secondary to the ingestion of substances derived from ergot alkaloids (Ergotamine). We present a clinical case of a young patient with the Human Immunodeficiency Virus, treated with antiretroviral protease inhibitors, which after self-medication with ergotamins suffered severe ischemia of the lower limbs, requiring admission to the intensive care center. This improved with intravenous vasodilators, achieving discharge to the ward with a virtually complete resolution.

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Author Biographies

Rosa Almeida

Servicio de Anestesiología. Hospital Central de las Fuerzas Armadas. Montevideo. Uruguay.

Leonardo Tolosa

Centro de tratamiento intensivo. Hospital Central de las Fuerzas Armadas. Montevideo. Uruguay.

References

(1) Cinfuentes MD, Blanco LS, Ramírez FC. Ergotis-mo por uso simultáneo de ergotamínico y terapia an-tirretroviral. Rev méd Chile [Internet]. 2016 June [citado 2018 Jun 12] ; 144 ( 6 ):807-812. Disponible en: https://scielo.conicyt.cl/scielo.php?script=sci_arttex-t&pid=S0034-98872016000600017&lng=en. http://dx.doi.org/10.4067/S0034-98872016000600017.

(2) Liegl C, Mc Grath M. Ergotism: Case Report and Review of the Literature. Int J Angiol 2016; 25(5):e8-e11.

(3) Avihingsanon A, Ramautarsing RA, Sawanpimolkul G, Chetchotisakd P, Bowonwatanuwong C, Jirajariyavei S, et al. Ergotism in Thailand caused by increased Access to antiretroviral drugs: a global warning. Top Antivir Med 2014; 21(5):165-8.

(4) Blanche P, Rigolet A, Gombert B, Ginsburg C, Salmon D, Sicard D. Ergotism related to a single doce of ergotamine in AIDS patient trated with ritonavir. Postgrad Med J 1999; 75 (887):546-7.

(5) Finn BC, Vadalá S, Meraldi A, Bruetman JE, Martínez JV, Young P. Ergotismo y HIV. Medicina (Bs As) 2013; 73(4):346-8.

Published

2018-12-03

How to Cite

1.
Almeida R, Tolosa L. Ergotism and antiretroviral protease inhibitors. Salud Mil [Internet]. 2018 Dec. 3 [cited 2026 May 26];37(2):55-8. Available from: https://revistasaludmilitar.uy/ojs/index.php/Rsm/article/view/7

Issue

Section

Case Reports

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