Hydrophilic matrices as drug release modulating agents.
DOI:
https://doi.org/10.35954/SM2007.29.1.2Keywords:
Kinetics; Dissolution; Release; Matrix.Abstract
To achieve prolonged effect of an active ingredient or drug, its release from the pharmaceutical form must be modulated. One form of modulation is through solid matrices, including hydrophilic matrices. The expected release rates of solid drugs incorporated in solid matrices are derived from mathematical models. In this work, two hydrophilic matrices were designed containing sodium alginate as a modulator of the release of the active ingredient diclofenac. The dissolution kinetics were determined by applying mathematical models of order zero and one. Likewise, the drug release mechanism was determined by applying diffusional and erodible models. Both formulations release it following first order kinetics and through an erosional mechanism with concomitant diffusion. The retention of diclofenac sodium is greater the higher the concentration of sodium alginate, and its release time from the pharmaceutical form is longer.
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