Pregnant with preeclampsia: uric acid as an early biomarker of severity
DOI:
https://doi.org/10.35954/SM2017.36.2.1Keywords:
Hyperuricemia; Pre-Eclampsia, Pregnant WomenAbstract
Objectives: to establish the relationship between hyperuricemia and the need for critical care in pregnant women; to demonstrate that increased uric acid is an early marker of severity. Method: we conducted a prospective descriptive analytical study of pregnant women at the Central Hospital of the Armed Forces between May 2014 and July 2015, requesting uricemia quantification in the second trimester of pregnancy routines. Medical records of 235 pregnant women, randomly selected from a total of 795 pregnant women in that period, were analyzed. The sample was divided into 3 groups: 1: control (pregnant women attended in gynecology-obstetrics polyclinic), 2: High Obstetric Risk polyclinic and 3: intensive care unit admissions. Data were analyzed with descriptive and analytical statistics using Pearson's Chi-square test and F and T tests. Results: the sample consisted of 235 pregnant women. Ages ranged from 14 to 42 years. Using Pearson's Chi-square test, we can affirm with 95% confidence that the control group has a significantly higher percentage of patients with uricemia lower than 4.5 mg/dl, and the High Obstetric Risk group has a significantly higher percentage of patients with uricemia higher than 4.5mg/dl. With the T-Test: the mean uricemia is statistically higher among patients admitted to the intensive care unit, with a confidence interval of 95%. The most frequent reasons for admission to the intensive care unit are severe preeclampsia and eclampsia. Preeclampsia in pregnant women admitted to the intensive care unit accounted for 2% of the total. Conclusions: patients admitted to the intensive care unit have uricemia higher or equal to 4.5 mg/dl; and the control group has uricemia lower than 4.5 mg/dl with statistical significance (p< 0.05). The uricemia level could be used in pregnant women as a marker of severity and risk of admission to the intensive care unit.
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